Modern life style affects eye condition

In modern society, PC or Smartphone have been essential tools. However, when you watch digital screens for hours, the eyes become dry and tired. The eyes would be further dryer if you watch them in the room with air conditioner. With these eyes dryness, the cornea in the eyes could be easily damaged and tear become unstable on eyes.

Then, the cornea damage makes eyes dry again. This is a vicious circle, and it leads to eye fatigue. Also, you may feel blurred vision in these eye condition.

Vitamin A are found to resolve the vicious circle

  Vitamin A is known as the “vitamin for the eyes.” Indeed, Vitamin A is necessary to for eyes to sense the light. In addition, recent studies have shown that it can prevent the eyes from losing its functions, and it has been a topic of interest.
  Lion found that Vitamin A accelerates production of mucin. It is a moisturizing substance in tears, and retains tears in the eye surface. Lion also found that Vitamin A promotes production of hyaluronic acid, a polymer that protects and repairs corneal epithelial cells.
  So that Vitamin A are found to resolve the vicious circle that may come from the modern society life style, and can improve the eye condition.

Lion’s long-term studies on
Vitamin A

Lion started study on vitamin A about 30 years ago.
Since then, we have been establishing the benefits of vitamin A for the eyes,
and developing Eye drops containing vitamin A.


• Effect of vitamin A palmitate on the synthesis of mucins in cultured conjunctiva. (Nippon Ganka Gakkai zasshi, 103, 580-583,1999)

• The effects of vitamin A compounds on hyaluronic acid released from cultured rabbit corneal epithelial cells and keratocytes. (Journal of Nutritional Science and Vitaminology 58, 223-229,2012)

• • Effect of Vitamin A Palmitate on Vitamin A-deficient Rabbits (Nippon Ganka Gakkai zasshi, 103,729-733,1999)

• Effect of retinol palmitate eye drops on experimental keratoconjunctival epithelial damage induced by n-heptanol in rabbit. (The Annual Meeting of the Association for Research in Vision and Ophthalmology, 2008) , (Curr Eye Res, 33,13-18,2008)

• Efficacy of retinol palmitate eye drops for dry eye in rabbits with lacrimal gland section. (Clinical Ophthalmology, 6, 1585-1593, 2012) Effect of retinol palmitate on corneal and conjunctival mucin gene expression in a rat dry eye model after injury. (J Ocul Pharmacol Ther 33:24-33. 2017)

• Efficacy and safety of retinol palmitate ophthalmic solution in the treatment of dry eye: a Japanese Phase clinical rial. (Drug Design, Development and Therapy, 11:1871-1879.2017)

The Funcion of the Mucin